Cardinals vs Chargers — Week 1 NFL Player Props & Matchup

Arizona Cardinals at Los Angeles Chargers · Sunday, September 13, 2026 · Sun 4:25 PM ET · Week 1 · 2026 season

Player props, odds and matchup context for Cardinals at Chargers in Week 1: both teams' FanDuel lines with hit rates at this week's numbers, spread, total and moneyline, injury designations, 2025 offensive pace, the defense-vs-position matchup, key players — build a Cardinals vs Chargers same-game parlay on ParlayBuilder.

Kickoff & Odds

TeamSpreadMoneyline
Arizona Cardinals +9.5 (-105) +410
Los Angeles Chargers -9.5 (-115) -550

Total: 47.5 (over -102 / under -120)

Cardinals vs Chargers Player Props (Week 1)

FanDuel main lines. "Last 10" counts past games that would have cleared this week's line; the 2025 column is the same count over that season including playoffs. Opponent rank: 1 = toughest of 32 against that position and market, 2025 season, opponent-adjusted.

Cardinals player props

PlayerPosMarketLineOver / UnderLast 102025ModelOpp rank
Jacoby BrissettQBPass TDs1.5+1548/1011/16—4th
Jacoby BrissettQBPass Yards221.5-114 / -1148/1010/16—6th
Jacoby BrissettQBRush Yards10.5-114 / -1145/107/16—15th
Jacoby BrissettQBAnytime TD—+9001/101/1611% to score16th
Tyler AllgeierRBAnytime TD—+2303/107/1727% to score5th
Jeremiyah LoveRBAnytime TD—+200———5th
Michael WilsonWRAnytime TD—+3305/106/1826% to score9th
Michael WilsonWRRec Yards41.5-114 / -1148/109/18—10th
Marvin Harrison Jr.WRAnytime TD—+2503/104/1322% to score9th
Marvin Harrison Jr.WRRec Yards48.5-114 / -1145/106/13—10th
Kendrick BourneWRAnytime TD—+6500/100/1810% to score9th
Kendrick BourneWRRec Yards16.5-114 / -1144/1011/18—10th
Michael WilsonWRReceptions3.5-122 / -1087/108/18—11th
Marvin Harrison Jr.WRReceptions3.5-172 / +1284/105/13—11th
Kendrick BourneWRReceptions2.5+134 / -1801/106/18—11th
Devin DuvernayWRAnytime TD—+25000/100/203% to score9th
Reggie VirgilWRAnytime TD—+2200———9th
Simi FehokoWRAnytime TD—+1600———9th
Trey McBrideTEAnytime TD—+2006/109/1837% to score11th
Trey McBrideTERec Yards56.5-114 / -1148/1012/18—7th
Trey McBrideTEReceptions6.5+116 / -1547/1010/18—2nd
Elijah HigginsTEAnytime TD—+10000/100/188% to score11th
Hunter LongTEAnytime TD—+22002/102/1110% to score11th

Chargers player props

PlayerPosMarketLineOver / UnderLast 102025ModelOpp rank
Justin HerbertQBPass TDs2.5+1741/103/18—26th
Justin HerbertQBPass Yards233.5-114 / -1143/108/18—18th
Justin HerbertQBRush Yards21.5-114 / -1146/1011/18—14th
Justin HerbertQBAnytime TD—+4302/102/1816% to score17th
Omarion HamptonRBAnytime TD—-1805/105/1135% to score28th
Omarion HamptonRBRush Yards65.5-114 / -1143/103/11—30th
Kimani VidalRBAnytime TD—+2503/104/1626% to score28th
Keaton MitchellRBAnytime TD—+2501/102/1413% to score28th
Omarion HamptonRBRec Yards12.5-114 / -1145/105/11—28th
Omarion HamptonRBReceptions2.5+124 / -1664/104/11—26th
Ladd McConkeyWRAnytime TD—+1254/106/1826% to score12th
Ladd McConkeyWRRec Yards50.5-114 / -1143/106/18—3rd
Quentin JohnstonWRAnytime TD—+1254/107/1629% to score12th
Quentin JohnstonWRRec Yards42.5-114 / -1143/107/16—3rd
Tre HarrisWRAnytime TD—+2700/101/2011% to score12th
Tre HarrisWRRec Yards26.5-114 / -1144/107/20—3rd
Ladd McConkeyWRReceptions4.5-102 / -1301/106/18—5th
Quentin JohnstonWRReceptions3.5+116 / -1544/108/16—5th
KeAndre Lambert-SmithWRAnytime TD—+7501/101/138% to score12th
Tre HarrisWRReceptions2.5-102 / -1303/105/20—5th
Derius DavisWRAnytime TD—+20000/100/135% to score12th
Brenen ThompsonWRAnytime TD—+750———12th
Oronde Gadsden IITEAnytime TD—+5501/104/1918% to score30th
David NjokuTEAnytime TD—+4104/104/1319% to score30th
Charlie KolarTEAnytime TD—+3201/102/196% to score30th
Charlie KolarTERec Yards16.5-114 / -1145/107/19—31st
Charlie KolarTEReceptions1.5-162 / +1221/103/19—30th

Injury Designations (through Sep 8)

Cardinals

  • Chase Bisontis G · IR
  • Jameson Geers TE · IR
  • Joey Blount S · IR
  • Kaleb Proctor DT · IR
  • Trey Benson RB · IR
  • Tip Reiman TE · PUP-R
  • James Conner RB · IR-R
  • Zachary Carter DT · IR-R

Chargers

  • Dalevon Campbell WR · IR
  • Denzel Perryman LB · IR
  • Tyler Biadasz C · IR
  • Isaiah World OT · NFI-R
  • Brenen Thompson WR · Questionable
  • Branson Taylor G · IR-R
  • Scott Matlock FB · IR-R

Offensive Profile (2025 season, through Week 18)

Per gameCardinalsChargers
Plays per game54.8 (28)60.9 (9)
Pass rate69.5% (1)54.9% (15)
Yards per game331.8354.2
Yards per play6.15.8
Pass attempts38.1 (1)33.5 (13)
Rush attempts16.7 (32)27.5 (15)
Targets per game34.2 (3)31.9 (11)
Offensive TDs2 (24)2.1 (23)

Ranks in parentheses are of 32 teams.

Defensive Matchup (2025 season, opponent-adjusted)

Rank 1 = toughest of 32 against that position and market, through Week 18.

Cardinals defense

  • vs quarterbacks: 18th in passing yards allowed, 26th in passing touchdowns allowed (one of the more generous), 22nd in interceptions forced (one of the more generous), 14th in rushing yards allowed, 17th in touchdowns allowed
  • vs running backs: 30th in rushing yards allowed (one of the more generous), 26th in receptions allowed (one of the more generous), 28th in receiving yards allowed (one of the more generous), 28th in touchdowns allowed (one of the more generous)
  • vs wide receivers: 3rd in receiving yards allowed (one of the tougher), 5th in receptions allowed (one of the tougher), 12th in touchdowns allowed
  • vs tight ends: 31st in receiving yards allowed (one of the more generous), 30th in receptions allowed (one of the more generous), 30th in touchdowns allowed (one of the more generous)

Chargers defense

  • vs quarterbacks: 6th in passing yards allowed (one of the tougher), 4th in passing touchdowns allowed (one of the tougher), 3rd in interceptions forced (one of the tougher), 15th in rushing yards allowed, 16th in touchdowns allowed
  • vs running backs: 9th in rushing yards allowed (one of the tougher), 3rd in receptions allowed (one of the tougher), 9th in receiving yards allowed (one of the tougher), 5th in touchdowns allowed (one of the tougher)
  • vs wide receivers: 10th in receiving yards allowed (one of the tougher), 11th in receptions allowed, 9th in touchdowns allowed (one of the tougher)
  • vs tight ends: 7th in receiving yards allowed (one of the tougher), 2nd in receptions allowed (one of the tougher), 11th in touchdowns allowed

Full defense-vs-position rankings →

Key Players

Cardinals

Chargers

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