Cardinals vs 49ers — Week 3 NFL Player Props & Matchup
Arizona Cardinals at San Francisco 49ers · Sunday, September 27, 2026 · Sun 4:05 PM ET · Week 3 · 2026 season
Player props, odds and matchup context for Cardinals at 49ers in Week 3: injury designations, 2026 offensive pace, the defense-vs-position matchup, key players — build a Cardinals vs 49ers same-game parlay on ParlayBuilder.
Injury Designations (through Sep 14)
Cardinals
- Chase Bisontis
- Jameson Geers
- Joey Blount
- Kaleb Proctor
- Trey Benson
- Tip Reiman
- Dadrion Taylor-Demerson
- Garrett Williams
- Isaiah Adams
- Kitan Crawford
- James Conner
- Zachary Carter
49ers
- Alfred Collins
- Andrew Farmer II
- Brett Toth
- Darrick Forrest
- Mikail Kamara
- Nate Hobbs
- Nick Martin
- Nick Zakelj
- Ricky Pearsall
- Sam Okuayinonu
- Brandon Aiyuk
- Isaac Guerendo
Offensive Profile (2026 season, through Week 1)
| Per game | Cardinals | 49ers |
|---|---|---|
| Plays per game | 71 | 64 |
| Pass rate | 52.1% | 53.1% |
| Yards per game | 393 | 379 |
| Yards per play | 5.5 | 5.9 |
| Pass attempts | 37 | 34 |
| Rush attempts | 34 | 30 |
| Targets per game | 37 | 33 |
| Offensive TDs | 2 | 3 |
Ranks in parentheses are of 32 teams.
Defensive Matchup (2025 season, opponent-adjusted)
Rank 1 = toughest of 32 against that position and market, through Week 18.
Cardinals defense
- vs quarterbacks: 18th in passing yards allowed, 26th in passing touchdowns allowed (one of the more generous), 22nd in interceptions forced (one of the more generous), 14th in rushing yards allowed, 17th in touchdowns allowed
- vs running backs: 30th in rushing yards allowed (one of the more generous), 26th in receptions allowed (one of the more generous), 28th in receiving yards allowed (one of the more generous), 28th in touchdowns allowed (one of the more generous)
- vs wide receivers: 3rd in receiving yards allowed (one of the tougher), 5th in receptions allowed (one of the tougher), 12th in touchdowns allowed
- vs tight ends: 31st in receiving yards allowed (one of the more generous), 30th in receptions allowed (one of the more generous), 30th in touchdowns allowed (one of the more generous)
49ers defense
- vs quarterbacks: 23rd in passing yards allowed (one of the more generous), 22nd in passing touchdowns allowed (one of the more generous), 25th in interceptions forced (one of the more generous), 9th in rushing yards allowed (one of the tougher), 5th in touchdowns allowed (one of the tougher)
- vs running backs: 14th in rushing yards allowed, 32nd in receptions allowed (one of the more generous), 27th in receiving yards allowed (one of the more generous), 19th in touchdowns allowed
- vs wide receivers: 21st in receiving yards allowed, 25th in receptions allowed (one of the more generous), 13th in touchdowns allowed
- vs tight ends: 20th in receiving yards allowed, 24th in receptions allowed (one of the more generous), 23rd in touchdowns allowed (one of the more generous)
Key Players
Cardinals
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