Cardinals vs 49ers — Week 3 NFL Player Props & Matchup
Arizona Cardinals at San Francisco 49ers · Sunday, September 27, 2026 · Sun 4:05 PM ET · Week 3 · 2026 season · Final
Player props, odds and matchup context for Cardinals at 49ers in Week 3: injury designations, 2026 offensive pace, the defense-vs-position matchup, key players — build a Cardinals vs 49ers same-game parlay on ParlayBuilder.
Injury Designations (through Oct 30)
Cardinals
- Chase Bisontis
- Hunter Long
- Isaiah Adams
- Jalen Brooks
- Joey Blount
- Kaleb Proctor
- Paris Johnson Jr.
- Trey Benson
- Will Johnson
- Tip Reiman
- Andrew Wingard
- Elijah Wilkinson
49ers
- Alfred Collins
- Andrew Farmer II
- C.J. West
- Darrick Forrest
- De'Zhaun Stribling
- Demarcus Robinson
- Jake Tonges
- Mikail Kamara
- Nate Hobbs
- Nick Martin
- Nick Zakelj
- Ricky Pearsall
Offensive Profile (2026 season, through Week 7)
| Per game | Cardinals | 49ers |
|---|---|---|
| Plays per game | 66.3 | 57.4 |
| Pass rate | 61% | 52.5% |
| Yards per game | 325.6 | 377.1 |
| Yards per play | 4.9 | 6.6 |
| Pass attempts | 40.4 | 30.1 |
| Rush attempts | 25.9 | 27.3 |
| Targets per game | 39 | 27.7 |
| Offensive TDs | 1.9 | 3.6 |
Ranks in parentheses are of 32 teams.
Defensive Matchup (2026 season, opponent-adjusted)
Rank 1 = toughest of 32 against that position and market, through Week 7.
Cardinals defense
- vs quarterbacks: 12th in passing yards allowed, 30th in passing touchdowns allowed (one of the more generous), 31st in interceptions forced (one of the more generous), 29th in rushing yards allowed (one of the more generous), 29th in touchdowns allowed (one of the more generous)
- vs running backs: 23rd in rushing yards allowed (one of the more generous), 1st in receptions allowed (one of the tougher), 12th in receiving yards allowed, 17th in touchdowns allowed
- vs wide receivers: 15th in receiving yards allowed, 4th in receptions allowed (one of the tougher), 30th in touchdowns allowed (one of the more generous)
- vs tight ends: 20th in receiving yards allowed, 23rd in receptions allowed (one of the more generous), 27th in touchdowns allowed (one of the more generous)
49ers defense
- vs quarterbacks: 18th in passing yards allowed, 23rd in passing touchdowns allowed (one of the more generous), 29th in interceptions forced (one of the more generous), 1st in rushing yards allowed (one of the tougher), 14th in touchdowns allowed
- vs running backs: 4th in rushing yards allowed (one of the tougher), 32nd in receptions allowed (one of the more generous), 32nd in receiving yards allowed (one of the more generous), 5th in touchdowns allowed (one of the tougher)
- vs wide receivers: 7th in receiving yards allowed (one of the tougher), 10th in receptions allowed (one of the tougher), 23rd in touchdowns allowed (one of the more generous)
- vs tight ends: 14th in receiving yards allowed, 27th in receptions allowed (one of the more generous), 16th in touchdowns allowed
Key Players
Cardinals
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