Lions vs Bills — Week 2 NFL Player Props & Matchup
Detroit Lions at Buffalo Bills · Thursday, September 17, 2026 · Thu 8:15 PM ET · Week 2 · 2026 season
Player props, odds and matchup context for Lions at Bills in Week 2: injury designations, 2025 offensive pace, the defense-vs-position matchup, key players — build a Lions vs Bills same-game parlay on ParlayBuilder.
Injury Designations (through Sep 8)
Lions
- Damone Clark
- Isiah Pacheco
- Kendrick Law
- Michael Niese
- Payton Turner
- Brian Branch
- Kerby Joseph
- Giovanni Manu
- Cade Mays
Bills
- Phidarian Mathis
- Tyrell Shavers
- Dorian Strong
- Zane Durant
Offensive Profile (2025 season, through Week 18)
| Per game | Lions | Bills |
|---|---|---|
| Plays per game | 60.2 | 61.2 |
| Pass rate | 56.9% | 47.6% |
| Yards per game | 388.7 | 393.6 |
| Yards per play | 6.5 | 6.4 |
| Pass attempts | 34.2 | 29.1 |
| Rush attempts | 25.9 | 32.1 |
| Targets per game | 32.4 | 28.1 |
| Offensive TDs | 3.3 | 3.5 |
Ranks in parentheses are of 32 teams.
Defensive Matchup (2025 season, opponent-adjusted)
Rank 1 = toughest of 32 against that position and market, through Week 18.
Lions defense
- vs quarterbacks: 21st in passing yards allowed, 19th in passing touchdowns allowed, 15th in interceptions forced, 2nd in rushing yards allowed (one of the tougher), 18th in touchdowns allowed
- vs running backs: 16th in rushing yards allowed, 8th in receptions allowed (one of the tougher), 14th in receiving yards allowed, 18th in touchdowns allowed
- vs wide receivers: 23rd in receiving yards allowed (one of the more generous), 19th in receptions allowed, 28th in touchdowns allowed (one of the more generous)
- vs tight ends: 22nd in receiving yards allowed (one of the more generous), 26th in receptions allowed (one of the more generous), 14th in touchdowns allowed
Bills defense
- vs quarterbacks: 2nd in passing yards allowed (one of the tougher), 14th in passing touchdowns allowed, 10th in interceptions forced (one of the tougher), 17th in rushing yards allowed, 22nd in touchdowns allowed (one of the more generous)
- vs running backs: 22nd in rushing yards allowed (one of the more generous), 10th in receptions allowed (one of the tougher), 8th in receiving yards allowed (one of the tougher), 27th in touchdowns allowed (one of the more generous)
- vs wide receivers: 5th in receiving yards allowed (one of the tougher), 8th in receptions allowed (one of the tougher), 11th in touchdowns allowed
- vs tight ends: 2nd in receiving yards allowed (one of the tougher), 1st in receptions allowed (one of the tougher), 19th in touchdowns allowed
Key Players
Lions
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