49ers vs Rams — Week 1 NFL Player Props & Matchup

San Francisco 49ers at Los Angeles Rams · Thursday, September 10, 2026 · Thu 8:35 PM ET · Week 1 · 2026 season

Player props, odds and matchup context for 49ers at Rams in Week 1: both teams' FanDuel lines with hit rates at this week's numbers, spread, total and moneyline, injury designations, 2025 offensive pace, the defense-vs-position matchup, key players — build a 49ers vs Rams same-game parlay on ParlayBuilder.

Kickoff & Odds

TeamSpreadMoneyline
San Francisco 49ers +3.5 (-106) +166
Los Angeles Rams -3.5 (-114) -198

Total: 48.5 (over -105 / under -115)

49ers vs Rams Player Props (Week 1)

FanDuel main lines. "Last 10" counts past games that would have cleared this week's line; the 2025 column is the same count over that season including playoffs. Opponent rank: 1 = toughest of 32 against that position and market, 2025 season, opponent-adjusted.

49ers player props

PlayerPosMarketLineOver / UnderLast 102025ModelOpp rank
Brock PurdyQBPass TDs1.5+102 / -1366/107/12—24th
Brock PurdyQBPass Yards243.5-114 / -1145/106/12—17th
Brock PurdyQBRush Yards17.5-114 / -1145/105/12—20th
Brock PurdyQBAnytime TD—+5502/102/1218% to score10th
Christian McCaffreyRBAnytime TD—-1507/1013/1956% to score11th
Christian McCaffreyRBRush Yards59.5-114 / -1145/108/19—15th
Christian McCaffreyRBRec Yards38.5-114 / -1146/1015/19—26th
Christian McCaffreyRBReceptions4.5-102 / -1307/1015/19—23rd
Jordan JamesRBAnytime TD—+9500/5——11th
Kaelon BlackRBAnytime TD—+950———11th
Deebo SamuelWRAnytime TD—+3502/106/1728% to score22nd
Deebo SamuelWRRec Yards29.5-114 / -1146/1010/17—22nd
Mike EvansWRAnytime TD—+2104/103/827% to score22nd
Mike EvansWRRec Yards49.5-114 / -1145/103/8—22nd
Demarcus RobinsonWRAnytime TD—+8002/103/1911% to score22nd
Demarcus RobinsonWRRec Yards11.5-114 / -1147/1013/19—22nd
Mike EvansWRReceptions3.5-130 / -1027/105/8—21st
Deebo SamuelWRReceptions2.5-140 / +1068/1013/17—21st
Demarcus RobinsonWRReceptions1.5+1586/1012/19—21st
George KittleTEAnytime TD—+2705/106/1231% to score18th
George KittleTERec Yards37.5-114 / -1147/107/12—8th
Jake TongesTEAnytime TD—+6501/105/2216% to score18th
George KittleTEReceptions3.5-130 / -1029/1010/12—9th

Rams player props

PlayerPosMarketLineOver / UnderLast 102025ModelOpp rank
Matthew StaffordQBPass TDs1.5-144 / +1089/1017/21—22nd
Matthew StaffordQBPass Yards263.5-114 / -1147/1012/21—23rd
Matthew StaffordQBRush Yards0.5+136 / -1784/107/21—9th
Matthew StaffordQBAnytime TD—+22000/100/218% to score5th
Kyren WilliamsRBAnytime TD—-1306/1013/2049% to score19th
Kyren WilliamsRBRush Yards55.5-114 / -1148/1016/20—14th
Blake CorumRBAnytime TD—+1554/106/2228% to score19th
Blake CorumRBRush Yards37.5-114 / -1147/1011/22—14th
Kyren WilliamsRBRec Yards10.5-114 / -1147/1014/20—27th
Kyren WilliamsRBReceptions1.5-148 / +1127/1014/20—32nd
Puka NacuaWRAnytime TD—+1256/1011/1945% to score13th
Puka NacuaWRRec Yards90.5-114 / -1146/1011/19—21st
Davante AdamsWRAnytime TD—+1206/1010/1746% to score13th
Davante AdamsWRRec Yards51.5-114 / -1147/1011/17—21st
Puka NacuaWRReceptions7.5+116 / -1545/1010/19—25th
Davante AdamsWRReceptions4.5-102 / -1304/107/17—25th
Konata MumpfieldWRAnytime TD—+14000/102/228% to score13th
Jordan WhittingtonWRAnytime TD—+7500/100/198% to score13th
Puka NacuaWRRush Yards2.5+102 / -1325/109/19——
CJ DanielsWRAnytime TD—+1400———13th
Colby ParkinsonTEAnytime TD—+4005/107/1826% to score23rd
Colby ParkinsonTERec Yards21.5-114 / -1149/1011/18—20th
Tyler HigbeeTEAnytime TD—+5503/103/1319% to score23rd
Tyler HigbeeTERec Yards13.5-114 / -1148/109/13—20th
Terrance FergusonTEAnytime TD—+4002/103/1713% to score23rd
Terrance FergusonTERec Yards23.5-114 / -1143/106/17—20th
Davis AllenTEAnytime TD—+14000/103/2112% to score23rd
Colby ParkinsonTEReceptions2.5+114 / -1488/1010/18—24th
Tyler HigbeeTEReceptions1.5-106 / -1257/108/13—24th
Terrance FergusonTEReceptions1.5-144 / +1082/104/17—24th

Injury Designations (through Sep 8)

49ers

  • Andrew Farmer II DE · IR
  • Brett Toth C · IR
  • Darrick Forrest S · IR
  • Mikail Kamara DE · IR
  • Nate Hobbs CB · IR
  • Nick Martin LB · IR
  • Nick Zakelj OT · IR
  • Ricky Pearsall WR · IR
  • Sam Okuayinonu DT · IR
  • Brandon Aiyuk WR · Reserve-DNR
  • Isaac Guerendo RB · PUP-R
  • Mykel Williams DE · PUP-R

Rams

  • Alex Johnson CB · IR
  • Daniel Rickert DE · IR
  • Eddie Walls III LB · IR
  • Keir Thomas II LB · IR
  • Matthew Caldwell QB · IR
  • Justin Dedich G · IR-R
  • Keagen Trost OT · IR-R

Offensive Profile (2025 season, through Week 18)

Per game49ersRams
Plays per game61.9 (7)62.5 (3)
Pass rate54.5% (16)56.2% (12)
Yards per game361.1403.5
Yards per play5.86.5
Pass attempts33.8 (11)35.1 (5)
Rush attempts28.2 (9)27.4 (16)
Targets per game30.6 (17)34.2 (4)
Offensive TDs2.8 (8)3.7 (1)

Ranks in parentheses are of 32 teams.

Defensive Matchup (2025 season, opponent-adjusted)

Rank 1 = toughest of 32 against that position and market, through Week 18.

49ers defense

  • vs quarterbacks: 23rd in passing yards allowed (one of the more generous), 22nd in passing touchdowns allowed (one of the more generous), 25th in interceptions forced (one of the more generous), 9th in rushing yards allowed (one of the tougher), 5th in touchdowns allowed (one of the tougher)
  • vs running backs: 14th in rushing yards allowed, 32nd in receptions allowed (one of the more generous), 27th in receiving yards allowed (one of the more generous), 19th in touchdowns allowed
  • vs wide receivers: 21st in receiving yards allowed, 25th in receptions allowed (one of the more generous), 13th in touchdowns allowed
  • vs tight ends: 20th in receiving yards allowed, 24th in receptions allowed (one of the more generous), 23rd in touchdowns allowed (one of the more generous)

Rams defense

  • vs quarterbacks: 17th in passing yards allowed, 24th in passing touchdowns allowed (one of the more generous), 7th in interceptions forced (one of the tougher), 20th in rushing yards allowed, 10th in touchdowns allowed (one of the tougher)
  • vs running backs: 15th in rushing yards allowed, 23rd in receptions allowed (one of the more generous), 26th in receiving yards allowed (one of the more generous), 11th in touchdowns allowed
  • vs wide receivers: 22nd in receiving yards allowed (one of the more generous), 21st in receptions allowed, 22nd in touchdowns allowed (one of the more generous)
  • vs tight ends: 8th in receiving yards allowed (one of the tougher), 9th in receptions allowed (one of the tougher), 18th in touchdowns allowed

Full defense-vs-position rankings →

Key Players

49ers

Rams

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