49ers vs Rams — Week 1 NFL Player Props & Matchup
San Francisco 49ers at Los Angeles Rams · Thursday, September 10, 2026 · Thu 8:35 PM ET · Week 1 · 2026 season · Final
Player props, odds and matchup context for 49ers at Rams in Week 1: injury designations, 2026 offensive pace, the defense-vs-position matchup, key players — build a 49ers vs Rams same-game parlay on ParlayBuilder.
Injury Designations (through Oct 8)
49ers
- Kyle Juszczyk
- Marques Sigle
- Alfred Collins
- Andrew Farmer II
- Brett Toth
- C.J. West
- Darrick Forrest
- De'Zhaun Stribling
- Demarcus Robinson
- Jake Tonges
- Mikail Kamara
- Nate Hobbs
Rams
- Daniel Rickert
- Eddie Walls III
- Keir Thomas II
- Matthew Caldwell
- Myles Garrett
- Ronnie Rivers
- Terrance Ferguson
- Aaron Donald
- Colby Parkinson
- Jaylen Watson
- Justin Dedich
- Keagen Trost
Offensive Profile (2026 season, through Week 4)
| Per game | 49ers | Rams |
|---|---|---|
| Plays per game | 57 | 67.5 |
| Pass rate | 49.6% | 61.1% |
| Yards per game | 389 | 427.2 |
| Yards per play | 6.8 | 6.3 |
| Pass attempts | 28.2 | 41.2 |
| Rush attempts | 28.8 | 26.2 |
| Targets per game | 25.8 | 39 |
| Offensive TDs | 4 | 2.5 |
Ranks in parentheses are of 32 teams.
Defensive Matchup (2026 season, opponent-adjusted)
Rank 1 = toughest of 32 against that position and market, through Week 4.
49ers defense
- vs quarterbacks: 12th in passing yards allowed, 15th in passing touchdowns allowed, 28th in interceptions forced (one of the more generous), 2nd in rushing yards allowed (one of the tougher), 22nd in touchdowns allowed (one of the more generous)
- vs running backs: 18th in rushing yards allowed, 32nd in receptions allowed (one of the more generous), 31st in receiving yards allowed (one of the more generous), 9th in touchdowns allowed (one of the tougher)
- vs wide receivers: 7th in receiving yards allowed (one of the tougher), 17th in receptions allowed, 21st in touchdowns allowed
- vs tight ends: 8th in receiving yards allowed (one of the tougher), 13th in receptions allowed, 2nd in touchdowns allowed (one of the tougher)
Rams defense
- vs quarterbacks: 2nd in passing yards allowed (one of the tougher), 21st in passing touchdowns allowed, 16th in interceptions forced, 9th in rushing yards allowed (one of the tougher), 24th in touchdowns allowed (one of the more generous)
- vs running backs: 17th in rushing yards allowed, 17th in receptions allowed, 9th in receiving yards allowed (one of the tougher), 2nd in touchdowns allowed (one of the tougher)
- vs wide receivers: 12th in receiving yards allowed, 12th in receptions allowed, 29th in touchdowns allowed (one of the more generous)
- vs tight ends: 2nd in receiving yards allowed (one of the tougher), 5th in receptions allowed (one of the tougher), 5th in touchdowns allowed (one of the tougher)
Key Players
49ers
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