49ers vs Rams — Week 1 NFL Player Props & Matchup
San Francisco 49ers at Los Angeles Rams · Thursday, September 10, 2026 · Thu 8:35 PM ET · Week 1 · 2026 season · Final
Player props, odds and matchup context for 49ers at Rams in Week 1: injury designations, 2026 offensive pace, the defense-vs-position matchup, key players — build a 49ers vs Rams same-game parlay on ParlayBuilder.
Injury Designations (through Oct 24)
49ers
- Deebo Samuel Sr.
- Garret Wallow
- Luke Gifford
- Marques Sigle
- Mike Evans
- Nick Bosa
- Alfred Collins
- Andrew Farmer II
- C.J. West
- Darrick Forrest
- De'Zhaun Stribling
- Demarcus Robinson
Rams
- Nate Landman
- Blake Grupe
- Daniel Rickert
- Davante Adams
- Eddie Walls III
- Kobie Turner
- Matthew Caldwell
- Myles Garrett
- Poona Ford
- Ronnie Rivers
- Terrance Ferguson
- Keir Thomas II
Offensive Profile (2026 season, through Week 7)
| Per game | 49ers | Rams |
|---|---|---|
| Plays per game | 56.5 | 66.7 |
| Pass rate | 50.4% | 63% |
| Yards per game | 371.5 | 413.8 |
| Yards per play | 6.6 | 6.2 |
| Pass attempts | 28.5 | 42 |
| Rush attempts | 28 | 24.7 |
| Targets per game | 26.2 | 40.3 |
| Offensive TDs | 3.7 | 2.8 |
Ranks in parentheses are of 32 teams.
Defensive Matchup (2026 season, opponent-adjusted)
Rank 1 = toughest of 32 against that position and market, through Week 7.
49ers defense
- vs quarterbacks: 15th in passing yards allowed, 16th in passing touchdowns allowed, 24th in interceptions forced (one of the more generous), 2nd in rushing yards allowed (one of the tougher), 20th in touchdowns allowed
- vs running backs: 15th in rushing yards allowed, 32nd in receptions allowed (one of the more generous), 31st in receiving yards allowed (one of the more generous), 18th in touchdowns allowed
- vs wide receivers: 13th in receiving yards allowed, 9th in receptions allowed (one of the tougher), 17th in touchdowns allowed
- vs tight ends: 11th in receiving yards allowed, 22nd in receptions allowed (one of the more generous), 3rd in touchdowns allowed (one of the tougher)
Rams defense
- vs quarterbacks: 2nd in passing yards allowed (one of the tougher), 12th in passing touchdowns allowed, 8th in interceptions forced (one of the tougher), 31st in rushing yards allowed (one of the more generous), 21st in touchdowns allowed
- vs running backs: 26th in rushing yards allowed (one of the more generous), 23rd in receptions allowed (one of the more generous), 30th in receiving yards allowed (one of the more generous), 4th in touchdowns allowed (one of the tougher)
- vs wide receivers: 6th in receiving yards allowed (one of the tougher), 4th in receptions allowed (one of the tougher), 28th in touchdowns allowed (one of the more generous)
- vs tight ends: 2nd in receiving yards allowed (one of the tougher), 1st in receptions allowed (one of the tougher), 1st in touchdowns allowed (one of the tougher)
Key Players
49ers
Set Parlay Odds
Build Parlay
or
Quick Add Props