Chargers vs Bills — Week 3 NFL Player Props & Matchup
Los Angeles Chargers at Buffalo Bills · Sunday, September 27, 2026 · Sun 1:00 PM ET · Week 3 · 2026 season
Player props, odds and matchup context for Chargers at Bills in Week 3: injury designations, 2026 offensive pace, the defense-vs-position matchup, key players — build a Chargers vs Bills same-game parlay on ParlayBuilder.
Injury Designations (through Sep 14)
Chargers
- Denzel Perryman
- Tyler Biadasz
- Isaiah World
- KeAndre Lambert-Smith
- Deane Leonard
- Derius Davis
- Elijah Molden
- Ladd McConkey
- Branson Taylor
- Scott Matlock
Bills
- Phidarian Mathis
- Tyrell Shavers
- Dorian Strong
- T.J. Sanders
- Terrel Bernard
- Ty Johnson
- Zane Durant
Offensive Profile (2026 season, through Week 1)
| Per game | Chargers | Bills |
|---|---|---|
| Plays per game | 48 | 50 |
| Pass rate | 56.2% | 58% |
| Yards per game | 290 | 420 |
| Yards per play | 6 | 8.4 |
| Pass attempts | 27 | 29 |
| Rush attempts | 21 | 21 |
| Targets per game | 27 | 28 |
| Offensive TDs | 2 | 4 |
Ranks in parentheses are of 32 teams.
Defensive Matchup (2025 season, opponent-adjusted)
Rank 1 = toughest of 32 against that position and market, through Week 18.
Chargers defense
- vs quarterbacks: 6th in passing yards allowed (one of the tougher), 4th in passing touchdowns allowed (one of the tougher), 3rd in interceptions forced (one of the tougher), 15th in rushing yards allowed, 16th in touchdowns allowed
- vs running backs: 9th in rushing yards allowed (one of the tougher), 3rd in receptions allowed (one of the tougher), 9th in receiving yards allowed (one of the tougher), 5th in touchdowns allowed (one of the tougher)
- vs wide receivers: 10th in receiving yards allowed (one of the tougher), 11th in receptions allowed, 9th in touchdowns allowed (one of the tougher)
- vs tight ends: 7th in receiving yards allowed (one of the tougher), 2nd in receptions allowed (one of the tougher), 11th in touchdowns allowed
Bills defense
- vs quarterbacks: 2nd in passing yards allowed (one of the tougher), 14th in passing touchdowns allowed, 10th in interceptions forced (one of the tougher), 17th in rushing yards allowed, 22nd in touchdowns allowed (one of the more generous)
- vs running backs: 22nd in rushing yards allowed (one of the more generous), 10th in receptions allowed (one of the tougher), 8th in receiving yards allowed (one of the tougher), 27th in touchdowns allowed (one of the more generous)
- vs wide receivers: 5th in receiving yards allowed (one of the tougher), 8th in receptions allowed (one of the tougher), 11th in touchdowns allowed
- vs tight ends: 2nd in receiving yards allowed (one of the tougher), 1st in receptions allowed (one of the tougher), 19th in touchdowns allowed
Key Players
Chargers
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