Chargers vs Bills — Week 3 NFL Player Props & Matchup
Los Angeles Chargers at Buffalo Bills · Sunday, September 27, 2026 · Sun 1:00 PM ET · Week 3 · 2026 season · Final
Player props, odds and matchup context for Chargers at Bills in Week 3: injury designations, 2026 offensive pace, the defense-vs-position matchup, key players — build a Chargers vs Bills same-game parlay on ParlayBuilder.
Injury Designations (through Oct 30)
Chargers
- Alec Ingold
- David Njoku
- Denzel Perryman
- Rashawn Slater
- Trevor Penning
- Trey Lance
- Trey Pipkins III
- Tyler Biadasz
- Derwin James Jr.
- Brenen Thompson
- Deane Leonard
- Donte Jackson
Bills
- Jordan Hancock
- C.J. Gardner-Johnson
- Tyrell Shavers
- Dorian Strong
- Bradley Chubb
- DJ Moore
- Dalton Kincaid
- Dee Alford
- Joe Andreessen
- Ray Davis
- Spencer Brown
- TJ Parker
Offensive Profile (2026 season, through Week 7)
| Per game | Chargers | Bills |
|---|---|---|
| Plays per game | 58.3 | 57.8 |
| Pass rate | 51.7% | 49.3% |
| Yards per game | 309.2 | 399.5 |
| Yards per play | 5.3 | 6.9 |
| Pass attempts | 30.2 | 28.5 |
| Rush attempts | 28.2 | 29.3 |
| Targets per game | 28.3 | 26.7 |
| Offensive TDs | 1.5 | 3.8 |
Ranks in parentheses are of 32 teams.
Defensive Matchup (2026 season, opponent-adjusted)
Rank 1 = toughest of 32 against that position and market, through Week 7.
Chargers defense
- vs quarterbacks: 5th in passing yards allowed (one of the tougher), 7th in passing touchdowns allowed (one of the tougher), 12th in interceptions forced, 12th in rushing yards allowed, 18th in touchdowns allowed
- vs running backs: 22nd in rushing yards allowed (one of the more generous), 7th in receptions allowed (one of the tougher), 4th in receiving yards allowed (one of the tougher), 25th in touchdowns allowed (one of the more generous)
- vs wide receivers: 12th in receiving yards allowed, 14th in receptions allowed, 21st in touchdowns allowed
- vs tight ends: 6th in receiving yards allowed (one of the tougher), 4th in receptions allowed (one of the tougher), 6th in touchdowns allowed (one of the tougher)
Bills defense
- vs quarterbacks: 29th in passing yards allowed (one of the more generous), 28th in passing touchdowns allowed (one of the more generous), 24th in interceptions forced (one of the more generous), 23rd in rushing yards allowed (one of the more generous), 10th in touchdowns allowed (one of the tougher)
- vs running backs: 13th in rushing yards allowed, 19th in receptions allowed, 17th in receiving yards allowed, 31st in touchdowns allowed (one of the more generous)
- vs wide receivers: 28th in receiving yards allowed (one of the more generous), 30th in receptions allowed (one of the more generous), 32nd in touchdowns allowed (one of the more generous)
- vs tight ends: 26th in receiving yards allowed (one of the more generous), 16th in receptions allowed, 2nd in touchdowns allowed (one of the tougher)
Key Players
Chargers
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